Tris buffer or tris(hydroxymethyl)aminomethane is a widely used chemical compound in biochemistry and molecular biology. It is used as a buffer for nucleic acid solutions and plays a vital role in laboratory research. Tris is also used in medicine as a drug to treat severe metabolic acidosis.

Tris (C4H11NO3) is a solid, colorless, odorless organic compound with a molarity of 121.14 g/mol and CAS number 77-86-1. As a primary amine, Tris participates in certain chemical reactions. It is widely used as a buffer in aqueous solutions and is an essential tool in biological research.